Live birth in woman with premature ovarian insufficiency and 46, XY karyotype after chemotherapy and bone marrow transplant: a case report

Live birth in woman with premature ovarian insufficiency and 46, XY karyotype after chemotherapy and bone marrow transplant: a case report

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Abstract Background Premature ovarian insufficiency (POI) is a clinical syndrome defined by loss of ovarian function before the age of 40 years, characterized by elevated serum gonadotropin levels and Goalie - Blockers - Senior decreased estrogen levels with menstrual disturbance.POI can be natural or iatrogenic such as after chemotherapy, radiotherapy and surgery.Case presentation In this study, we describe a successful live birth in a 31-year-old woman with POI and 46, XY Karyotype after being treated with chemotherapy and bone marrow transplant (BMT) for acute non-lymphocytic leukemia when she was 17 years old.With amenorrhea or oligomenorrhea for 11 years, her serum level of FSH was up to 35.0 IU/L and 53.

0 IU/L taken 4 weeks apart, which can be diagnosed as POI.After controlled ovarian stimulation treatment for three cycles with different protocols and frozen-thawed embryo transfer (FET), she finally got a successful pregnancy and had a live birth later.Conclusions This case report serves as a reminder that karyotype of peripheral blood may mislead the diagnosis as disorders of sex development (DSD).It also demonstrates that it is possible for a woman with chemotherapy and bone marrow transplant induced POI can have successful pregnancy and live birth with appropriate therapy.Furthermore, as age may plays a predominant Toddler Outerwear role in fertility rather than residual ovarian reserve, active treatment may be concerned for women with POI at younger age.